aurka inhibitor Search Results


lentiviruses containing an aurka inhibitor sequence  (Shanghai Genechem Ltd)
90
Shanghai Genechem Ltd lentiviruses containing an aurka inhibitor sequence
Lentiviruses Containing An Aurka Inhibitor Sequence, supplied by Shanghai Genechem Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/lentiviruses containing an aurka inhibitor sequence/product/Shanghai Genechem Ltd
Average 90 stars, based on 1 article reviews
lentiviruses containing an aurka inhibitor sequence - by Bioz Stars, 2026-02
90/100 stars
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aurka inhibitor (mk-8745  (Merck & Co)
90
Merck & Co aurka inhibitor (mk-8745
Aurka Inhibitor (Mk 8745, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aurka inhibitor (mk-8745/product/Merck & Co
Average 90 stars, based on 1 article reviews
aurka inhibitor (mk-8745 - by Bioz Stars, 2026-02
90/100 stars
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aurora-a kinase inhibitor mk-5108  (Merck & Co)
90
Merck & Co aurora-a kinase inhibitor mk-5108
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Aurora A Kinase Inhibitor Mk 5108, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aurora-a kinase inhibitor mk-5108/product/Merck & Co
Average 90 stars, based on 1 article reviews
aurora-a kinase inhibitor mk-5108 - by Bioz Stars, 2026-02
90/100 stars
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second-generation aurka inhibitor alisertib  (Millennium Pharmaceuticals)
90
Millennium Pharmaceuticals second-generation aurka inhibitor alisertib
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Second Generation Aurka Inhibitor Alisertib, supplied by Millennium Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/second-generation aurka inhibitor alisertib/product/Millennium Pharmaceuticals
Average 90 stars, based on 1 article reviews
second-generation aurka inhibitor alisertib - by Bioz Stars, 2026-02
90/100 stars
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aurka inhibitor alisertib  (Beijing Tiantan Biological)
90
Beijing Tiantan Biological aurka inhibitor alisertib
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Aurka Inhibitor Alisertib, supplied by Beijing Tiantan Biological, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aurka inhibitor alisertib/product/Beijing Tiantan Biological
Average 90 stars, based on 1 article reviews
aurka inhibitor alisertib - by Bioz Stars, 2026-02
90/100 stars
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aurka inhibitor  (MultiTarget Pharmaceuticals)
90
MultiTarget Pharmaceuticals aurka inhibitor
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Aurka Inhibitor, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aurka inhibitor/product/MultiTarget Pharmaceuticals
Average 90 stars, based on 1 article reviews
aurka inhibitor - by Bioz Stars, 2026-02
90/100 stars
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aurora kinase a (aurka) specific inhibitor ak-01  (ChemieTek LLC)
90
ChemieTek LLC aurora kinase a (aurka) specific inhibitor ak-01
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Aurora Kinase A (Aurka) Specific Inhibitor Ak 01, supplied by ChemieTek LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aurora kinase a (aurka) specific inhibitor ak-01/product/ChemieTek LLC
Average 90 stars, based on 1 article reviews
aurora kinase a (aurka) specific inhibitor ak-01 - by Bioz Stars, 2026-02
90/100 stars
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cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)pyrimidin-2-ylamino)-phenyl)-amide  (Merck & Co)
90
Merck & Co cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)pyrimidin-2-ylamino)-phenyl)-amide
<t>MK-5108</t> induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.
Cyclopropanecarboxylic Acid (3 (4 (3 Trifluoromethyl Phenylamino)Pyrimidin 2 Ylamino) Phenyl) Amide, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)pyrimidin-2-ylamino)-phenyl)-amide/product/Merck & Co
Average 90 stars, based on 1 article reviews
cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)pyrimidin-2-ylamino)-phenyl)-amide - by Bioz Stars, 2026-02
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Image Search Results


MK-5108 induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108 induce cell death in EOC stem cells. EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 for 72 hr. (A) Growth rate was determined using the Incucyte real-time video imaging system; (B) Cell viability was determined using CellTiter 96 assay; (C) Representative immunofluorescence images of control and MK-5108-treated EOC stem cells. Cells were stained with propidium iodide (red) and F-actin (green). Nuclei were visualized by 4′,6-diamidino-2-phenylindole (DAPI) staining (blue). Representative data shown are for EOC stem cell 1.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Imaging, Immunofluorescence, Staining

MK-5108's effect on the caspase cascade in EOC stem cells. (A) EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 and activity of caspase 3/7 measured using CaspaseGlo. (B) Microscopic analysis showed multi-nucleated cells (black arrow). Representative data shown are for EOC stem cell 1.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108's effect on the caspase cascade in EOC stem cells. (A) EOC stem cells were treated with DMSO vehicle or increasing doses of MK-5108 and activity of caspase 3/7 measured using CaspaseGlo. (B) Microscopic analysis showed multi-nucleated cells (black arrow). Representative data shown are for EOC stem cell 1.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Activity Assay

MK-5108 arrests EOC stem cells in G2/M phase. EOC stem cells were treated with DMSO vehicle or 5 µM MK-5108 for 24 h or 48 h and cell cycle analysis performed with propidium iodide staining and flow cytometry. Representative data shown are for EOC stem cell 1.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108 arrests EOC stem cells in G2/M phase. EOC stem cells were treated with DMSO vehicle or 5 µM MK-5108 for 24 h or 48 h and cell cycle analysis performed with propidium iodide staining and flow cytometry. Representative data shown are for EOC stem cell 1.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Cell Cycle Assay, Staining, Flow Cytometry

MK-5108 inhibits constitutive NFκB activity and constitutive cytokine secretion in the EOC stem cells. (A) EOC stem cells were treated with 5 µM of MK-5108 prior to treatment with 10 ng/ml TNFα. NFκB activity was measured using a luciferase reporter system. Bars show mean ± SEM. *p < 0.01 compared to control, **p < 0.01 compared to TNFα alone; (C) levels of secreted cytokines and chemokines were quantified in cell supernatants using xMAP technology. Representative data shown are for EOC stem cell 1.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108 inhibits constitutive NFκB activity and constitutive cytokine secretion in the EOC stem cells. (A) EOC stem cells were treated with 5 µM of MK-5108 prior to treatment with 10 ng/ml TNFα. NFκB activity was measured using a luciferase reporter system. Bars show mean ± SEM. *p < 0.01 compared to control, **p < 0.01 compared to TNFα alone; (C) levels of secreted cytokines and chemokines were quantified in cell supernatants using xMAP technology. Representative data shown are for EOC stem cell 1.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Activity Assay, Luciferase

MK-5108 promotes accumulation of nuclear IκBα. (A) EOC stem cells were treated with 5 µM MK-5108 at time points shown and levels of IκBα determined in cytoplasmic and nuclear fractions by western blot analysis. (B) Densitometer graphs depicting IκBα levels normalized to topoisomerase (for nuclear fraction) and to actin (for cytoplasmic fraction). Representative data shown are for EOC stem cell 1.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108 promotes accumulation of nuclear IκBα. (A) EOC stem cells were treated with 5 µM MK-5108 at time points shown and levels of IκBα determined in cytoplasmic and nuclear fractions by western blot analysis. (B) Densitometer graphs depicting IκBα levels normalized to topoisomerase (for nuclear fraction) and to actin (for cytoplasmic fraction). Representative data shown are for EOC stem cell 1.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Western Blot

MK-5108 inhibits TNFα-induced NFκB activity in the EOC stem cells. (A) EOC stem cells were treated with 5 µM of MK-5108 prior to treatment with 10 ng/ml TNFα. Levels of nuclear p65 was determined by immunofluorescence with Hoechst dye.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: MK-5108 inhibits TNFα-induced NFκB activity in the EOC stem cells. (A) EOC stem cells were treated with 5 µM of MK-5108 prior to treatment with 10 ng/ml TNFα. Levels of nuclear p65 was determined by immunofluorescence with Hoechst dye.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Activity Assay, Immunofluorescence

Proposed model for the role of MK-5108 in EOC stem cells on NFκB activity, see text for description.

Journal: Cell Cycle

Article Title: Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NF?B pathway

doi: 10.4161/cc.10.13.16348

Figure Lengend Snippet: Proposed model for the role of MK-5108 in EOC stem cells on NFκB activity, see text for description.

Article Snippet: Aurora-A Kinase inhibitor MK-5108 was provided by Merck (Whitehouse Station, NJ).

Techniques: Activity Assay